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Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D<sub>2</sub>
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- Kotoku Naoyuki
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Mizushima Kohei
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Tamura Satoru
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Kobayashi Motomasa
- Graduate School of Pharmaceutical Sciences, Osaka University
Bibliographic Information
- Other Title
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- Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D₂
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Description
Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 61 (10), 1024-1029, 2013
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679153999360
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- NII Article ID
- 130004137256
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2c%2FlvVejug%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 024872826
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- PubMed
- 24088693
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed