Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D₂
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- Kotoku Naoyuki
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Mizushima Kohei
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Tamura Satoru
- Graduate School of Pharmaceutical Sciences, Osaka University
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- Kobayashi Motomasa
- Graduate School of Pharmaceutical Sciences, Osaka University
書誌事項
- タイトル別名
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- Synthetic Studies of Cortistatin A Analogue from the CD-Ring Fragment of Vitamin D<sub>2</sub>
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説明
Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D2. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 61 (10), 1024-1029, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679153999360
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- NII論文ID
- 130004137256
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2c%2FlvVejug%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024872826
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- PubMed
- 24088693
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- KAKEN
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
