Cyclic Sulfoxides Garlicnins B<sub>2</sub>, B<sub>3</sub>, B<sub>4</sub>, C<sub>2</sub>, and C<sub>3</sub> from <i>Allium sativum</i>
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- Nohara Toshihiro
- Faculty of Pharmaceutical Sciences, Sojo University
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- Fujiwara Yukio
- Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University
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- Ikeda Tsuyoshi
- Faculty of Pharmaceutical Sciences, Sojo University
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- Murakami Kohtaro
- Faculty of Pharmaceutical Sciences, Sojo University
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- Ono Masateru
- School of Agriculture, Tokai University
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- Nakano Daisuke
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Kinjo Junei
- Faculty of Pharmaceutical Sciences, Fukuoka University
Bibliographic Information
- Other Title
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- Cyclic Sulfoxides Garlicnins B₂, B₃, B₄, C₂, and C₃ from Allium sativum
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Abstract
Several novel sulfides, called garlicnins B2 (1), B3 (2), B4 (3), C2 (4), and C3 (5), were isolated from acetone extracts of garlic, Allium sativum L. and characterized. These garlicnins are capable of suppressing M2 macrophage activation and they have a novel skeleton of cyclic sulfoxide. The structures of the former 3 and latter of 2 were deduced to be 2-(sulfenic acid)-5-(allyl)-3,4-dimethyltetrahydrothiophene-S-oxides and 2-(allyldithiine)-5-(propenylsulfoxide)-3,4-dimethyltetrahydrothiophene-S-oxides, respectively. The mechanism of the proposed production of these compounds is discussed. The identification of these novel sulfoxides from garlic accumulates a great deal of new chemistry in the Allium sulfide field, and future pharmacological investigations of these compounds will aid the development of natural, healthy foods and anti-cancer agents that may prevent or combat disease.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 61 (7), 695-699, 2013
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282679154249600
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- NII Article ID
- 130003360797
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3sjmsVyquw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 024644816
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- PubMed
- 23812395
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed