Synthesis and Antibacterial Activities of Yanglingmycin Analogues

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  • Li Long-Bo
    College of Sciences, Northwest A & F University Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide
  • Dan Wen-Jia
    College of Sciences, Northwest A & F University Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide
  • Tan Fang-Fang
    College of Sciences, Northwest A & F University Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide
  • Cui Li-Hui
    College of Sciences, Northwest A & F University Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide
  • Yuan Zhi-Peng
    College of Sciences, Northwest A & F University Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide
  • Wu Wen-Jun
    Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A & F University
  • Zhang Ji-Wen
    College of Sciences, Northwest A & F University Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide

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The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 µg/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides.

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