Studies on the Synthesis of 4-Methoxypyrimidine 1-Oxide and its Reissert Reaction.

Description

4-Methoxypyrimidine 1-oxide was prepared and its Reissert reaction afforded 4-methoxypyrimidine-2-carbonitrile, which was derived to 2, 4-dimethoxypyrimidine to confirm the structure. At the same time, difference in the nucleophilic activity of the 2-and 4-positions in pyrimidine 1-oxide was clarified. During the course of this work, a simple process for the preparation of 4-methoxypyrimidine was established.

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