In Vitro Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions
-
- Liu Chi-Hsien
- Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology
-
- Lai Kuan-Yu
- Chemical and Materials Engineering Department, Chang Gung University
-
- Wu Wei-Chi
- College of Medicine, Chang Gung University Department of Ophthalmology, Chang Gung Memorial Hospital
-
- Chen Yu-Jui
- Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University
-
- Lee Wei-Shiou
- Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University
-
- Hsu Ching-Yun
- Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology
書誌事項
- タイトル別名
-
- <i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions
この論文をさがす
抄録
Lutein is a macular pigment that contributes to maintaining eye health. The development of lutein-laden nanocarriers for ocular delivery would have the advantages of user friendliness and cost-effectiveness. Nano-scaled vehicles such as cyclodextrin (CD) and nanoemulsion could overcome the barriers caused by the scleral structure. This study focused on the development of hybrid nanocarriers containing nanoemulsion and CD for scleral lutein accumulation. In the presence of the nanoemulsion, CD forms such as βCD and hydroxyethyl (HE) βCD increased the partition of lutein into the porcine sclera. A combination of nanoemulsion and 2% HEβCD enhanced lutein accumulation to 119±6 µg g−1 h−1, which was 9.2-fold higher than that with lutein suspension alone. We explored the dose effect of CD in nanoemulsion on scleral lutein and found that the scleral accumulation of lutein was enhanced by increasing the CD content. The novel nanoemulsion had 95% drug-loading efficiency and low cytotoxicity in retinal cells. The CD-modified nanoemulsion not only improved the stability and entrapment efficacy of lutein in the aqueous system but also enhanced scleral lutein accumulation. An increase in the partition coefficient of lutein in porcine sclera when using the CD-modified nanoemulsion was also confirmed.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 63 (2), 59-67, 2015
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679154730624
-
- NII論文ID
- 130004803763
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 026069285
-
- PubMed
- 25748776
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可