Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites
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- Muratake Hideaki
- Research Foundation Itsuu Laboratory
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- Amano Yohei
- Research Foundation Itsuu Laboratory
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- Toda Takahiro
- Research Foundation Itsuu Laboratory
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- Sugiyama Kiyoshi
- Department of Clinical Pharmacokinetics, Hoshi University
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- Shudo Koichi
- Research Foundation Itsuu Laboratory
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抄録
Compound 1 (IT-M-07000) was previously reported as a candidate prodrug of Am80 (Tamibarotene; used to treat acute promyelocytic leukemia), and shown to be efficiently metabolized to Am80 via β-oxidation. Here, we describe in detail the synthesis of 1, together with another tetradeuterated candidate prodrug, IT-YA-00616 (2), as well as two congeners, and several metabolic intermediates of 1 previously detected in mouse plasma.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 61 (8), 846-852, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679155032960
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- NII論文ID
- 130003360816
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3sflslWjug%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024715356
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- PubMed
- 23902867
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可