Synthesis and Protective Effects of Bis{4-[<i>N</i>,<i>N</i>-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts
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- Hsu Ling-Yih
- Department of Biological Science and Technology, China University of Science and Technology
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- Nien Chih-Ying
- School of Pharmacy, National Defense Medical Center
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- Huang Wei-Ming
- Department of Biochemistry, National Defense Medical Center
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- Hsu Shou-Che
- Department of Biochemistry, National Defense Medical Center
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- Chang Tsu-Chung
- Department of Biotechnology, Asia University Graduate Institute of Basic Medical Science, China Medical University Department of Biochemistry, National Defense Medical Center
Bibliographic Information
- Other Title
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- Synthesis and Protective Effects of Bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane Derivatives on UVA-Induced Production of MMP-1 in Human Skin Fibroblasts
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Abstract
UV-induced matrix metalloproteinase (MMP) production is considered a cause of skin aging. In this study, a number of novel bis{4-[N,N-di-(carboxymethyl)amino]phenoxy}alkane derivatives were synthesized and evaluated as UVA-protective agents. These compounds significantly protected human dermal fibroblast (HDF) cells from UVA-induced cytotoxicity and inhibited MMP-1 activation and expression with potency comparable to desferoxamine (DFO). Promoter activity assay indicated that they inhibited MMP-1 expression at the transcriptional level. Further studies revealed that the mechanism of these compounds may include blockage of the UVA-induced activation of the p38/mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) pathways. Together, these results suggest that further development of these compounds may be of interest.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 62 (9), 867-874, 2014
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679155095296
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- NII Article ID
- 130004684766
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2M%2FmvFKisw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 025736811
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- PubMed
- 25177015
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed