Total Synthesis of Biologically Active Natural Products Based on Highly Selective Synthetic Methodologies
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- Hatakeyama Susumi
- Graduate School of Biomedical Sciences, Nagasaki University, 1–14 Bunkyo-machi, Nagasaki 852–8521, Japan
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Abstract
Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita–Baylis–Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C–H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 62 (11), 1045-1061, 2014
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679155139584
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- NII Article ID
- 130004712908
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 025880428
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- PubMed
- 25366310
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed