An Efficient Method for the Synthesis of 2′,3′-Nonsubstituted Cycloalkane-1,3-dione-2-spirocyclopropanes Using (2-Bromoethyl)diphenylsulfonium Trifluoromethanesulfonate
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- Nambu Hisanori
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Ono Naoki
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Hirota Wataru
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Fukumoto Masahiro
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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- Yakura Takayuki
- Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Bibliographic Information
- Other Title
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- An Efficient Method for the Synthesis of 2',3'-Nonsubstituted Cycloalkane-1,3-dione-2-spirocyclopropanes Using (2-Bromoethyl)diphenylsulfonium Trifluoromethanesulfonate
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Abstract
<p>An efficient and practical synthesis of 2′,3′-nonsubstituted cyclohexane-1,3-dione-2-spirocyclopropanes using a sulfonium salt was achieved. The reaction of 1,3-cyclohexanediones and (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate with powdered K2CO3 in EtOAc at room temperature (r.t.) provided the corresponding spirocyclopropanes in high yields. The synthetic method was also applied to 1,3-cyclopentanedione, 1,3-cycloheptanedione, 1,3-indanedione, acyclic 1,3-diones, ethyl acetoacetate, and Meldrum’s acid.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 64 (12), 1763-1768, 2016
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282679155145856
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- NII Article ID
- 130005170648
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 027752849
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- PubMed
- 27904084
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed