Studies on Catalytic Activation of Olefins Using Cobalt Complex

DOI Web Site Web Site PubMed 被引用文献2件 参考文献21件 オープンアクセス

この論文をさがす

抄録

<p>In this review, I tell the story of the cobalt chemistry that has been developed in my group since 2011. First, we achieved the total synthesis of polyketide natural product trichodermatide A, which involved a late-stage Isayama-Mukaiyama hydration of an enol ether using cobalt(II) acetylacetonate (Co(acac)2) that gave the desired product chemo-, regio-, and diastereoselectively. After our report of this total synthesis in 2013, we were required to revise the originally reported structure of trichodermatide A following the accurate and important report from the Trauner group. Second, we found unique cobalt-catalyzed hydroelementation reactions of olefins involving a cobalt-salen complex, N-fluoro-2,4,6-trimethylpyridinium salt, and a silane reagent. Under these reaction conditions, a carbocationic or carbon radical species is generated from an olefin, and then C–X (X=O, N, C, F) bond formation occurs with good functional group tolerance for a broad substrate scope. This review also covers recent examples of switching chemistry and natural product synthesis involving my cobalt chemistry reported by several groups.</p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (21)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ