Bromopyrrole Alkaloids from Okinawan Marine Sponges Agelas spp

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  • Tanaka Naonobu
    Graduate School of Pharmaceutical Sciences, Hokkaido University Graduate School of Pharmaceutical Sciences, Tokushima University
  • Kusama Taishi
    Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Kashiwada Yoshiki
    Graduate School of Pharmaceutical Sciences, Tokushima University
  • Kobayashi Jun’ichi
    Graduate School of Pharmaceutical Sciences, Hokkaido University

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タイトル別名
  • Bromopyrrole Alkaloids from Okinawan Marine Sponges <i>Agelas</i> spp.

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In our continuing study for structurally and biogenetically interesting natural products from marine organisms, Okinawan marine sponges Agelas spp. were investigated, resulting in the isolation of 18 unique alkaloids including five dimeric bromopyrrole alkaloids (1–5), ten monomeric bromopyrrole alkaloids (6–15), and three conjugates of monomeric bromopyrrole alkaloid and hydroxykynurenine (16–18). In this mini-review, the isolation, structure elucidation, and antimicrobial activities of these alkaloids are summarized.

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