Nocapyrones H–J, 3,6-Disubstituted α-Pyrones from the Marine Actinomycete <i>Nocardiopsis</i> sp. KMF-001

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  • Kim Min Cheol
    Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung Graduate School of East-West Medical Science, Kyung Hee University
  • Kwon Oh-Wook
    Graduate School of East-West Medical Science, Kyung Hee University
  • Park Jin-Soo
    Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung
  • Kim Sun Yeou
    Department of Pharmacy, Gachon University
  • Kwon Hak Cheol
    Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung

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  • Nocapyrones H-J, 3,6-Disubstituted α-Pyrones from the Marine Actinomycete Nocardiopsis sp. KMF-001

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Three new 3,6-disubstituted α-pyrones, nocapyrones H–J (1–3), were isolated from the marine actinomycete Nocardiopsis sp. KMF-001. Their structures were assigned to be 3-alkylated 6-(1-methyl-1-propenyl)-2H-pyran-2-ones on the basis of UV, MS, NMR, and high resolution (HR)-FAB-MS analyses. Nocapyrone H (1) reduced the pro-inflammatory factor such as nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-1β (IL-1β). Moreover, nocapyrone H showed 5.82% stronger inhibitory effect on NO production than chrysin at a concentration of 10 µm in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.

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