Synthesis and in Vitro Antiproliferative Evaluation of Novel Hybrids from 1,3,4-Thiadiazole and Benzisoselenazolone

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  • Jing Fen
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Fu Xiaoyun
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Li Sha
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Li Baolin
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Zhao Jijun
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Wang Xuefeng
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Liu Yuming
    School of Chemistry and Chemical Engineering, Tianjin University of Technology
  • Chen Baoquan
    School of Chemistry and Chemical Engineering, Tianjin University of Technology

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  • Synthesis and <i>in Vitro</i> Antiproliferative Evaluation of Novel Hybrids from 1,3,4-Thiadiazole and Benzisoselenazolone

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Novel hybrids from 1,3,4-thiadiazole and benzisoselenazolone were designed, synthesized and evaluated for their in vitro antiproliferative activities by CCK-8 assay against three types of human cancer cell lines, SMMC-7721, MCF-7 and A549 cells. The preliminary bioassay results demonstrated that all tested compounds 4a–p showed potent antiproliferative activities, and some compounds exhibited better effects than positive control ethaselen and 5-fluorouracil (5-FU) against various cancer cell lines. Furthermore, compound 4g showed significant antiproliferative activities against SMMC-7721 cells with an IC50 value of 2.08 µM. Compounds 4b and 4m displayed highly effective biological activities against MCF-7 cells with an IC50 values of 2.03 and 2.06 µM, respectively. Compound 4i exhibited the best inhibitory effect against A549 cells with an IC50 value of 1.03 µM.

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