Synthesis of Novel Phosphorylated Guanidine Derivatives from Cyanamide and Their Anti-inflammatory Activity
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- Katla Venkata Ramana
- Department of Chemistry, Sri Venkateswara University
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- Syed Rasheed
- Department of Chemistry, Sri Venkateswara University
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- Kuruva Chandra Sekhar
- Department of Chemistry, Sri Venkateswara University
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- Kuntrapakam Hema Kumar
- Aptus BioSciences Private Limited
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- Chamarthi Naga Raju
- Department of Chemistry, Sri Venkateswara University
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説明
A series of novel guanidine derivatives were synthesized in three steps and their anti-inflammatory activities in vitro and in vivo evaluated. 2-Aminopyridin-3-ol (1) was reacted with thiophosphoryl chloride (2) to give a monochloride (3). It was further reacted with cyanamide to afford the corresponding cyanamine (4), which was subsequently reacted with different heterocyclic amines to form the title compounds (5a–l). The substituent in the guanidine function affected the potency of anti-inflammatory activity. The compounds having benzothiazole, fluorophenyl, and piperazinyl moieties enhanced the anti-inflammatory activity.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 61 (1), 25-32, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679155617792
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- NII論文ID
- 130003360715
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3s3otFWltQ%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024173877
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- PubMed
- 23302584
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可