Synthesis and Neuroprotective Effects of the Fluorine Substituted Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and Serum Limitation
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- Yang Xiaoming
- JiangSu Key Laboratory of Neuroregeneration, Nantong University
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- Xu Wen
- JiangSu Key Laboratory of Neuroregeneration, Nantong University
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- Zhao Weijia
- School of Life Sciences, Nantong University
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- Zhao Yahong
- JiangSu Key Laboratory of Neuroregeneration, Nantong University
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- Yang Yumin
- JiangSu Key Laboratory of Neuroregeneration, Nantong University
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- Ling Yong
- Department of Pharmacy, School of Medical, Nantong University
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抄録
Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L., a traditional Chinese medicinal plant, which elicits neuroprotective effects in the treatment of ischemic stroke. In an attempt to improve its neuroprotective effects, fluorine substituted Sal analogues were synthesized and their neuroprotective activities against the hypoglycemia and serum limitation induced cell injury in differentiated PC12 cells were evaluated. The target compounds displayed strong protective effects on the cell viability against the damage caused by hypoglycemia and serum limitation, especially for D1, which had a great potency superior to Sal and efficiently inhibited hypoglycemia and serum limitation induced cell nuclear morphologic changes and the increased apoptotic rate in a dose-dependent manner. These new findings may provide potentially important information for further development of Sal analogues and lay the basis for further studies on the cerebral ischemic stroke and neurodegenerative diseases for human clinical treatment.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 61 (11), 1192-1196, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679155726976
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- NII論文ID
- 130003381782
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2c7ivFyisQ%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024957275
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- PubMed
- 24189306
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可