Determination of Useful Ranges of Mixing Conditions for Glycerin Fatty Acid Ester by Multiple Regression Analysis
-
- Uchimoto Takeaki
- Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka
-
- Iwao Yasunori
- Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka
-
- Hattori Hiroaki
- Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka
-
- Noguchi Shuji
- Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka
-
- Itai Shigeru
- Department of Pharmaceutical Engineering, School of Pharmaceutical Sciences, University of Shizuoka
この論文をさがす
抄録
The interaction of the effects of the triglycerin full behenate (TR-FB) concentration and the mixing time on lubrication and tablet properties were analyzed under a two-factor central composite design, and compared with those of magnesium stearate (Mg-St). Various amounts of lubricant (0.07–3.0%) were added to granules and mixed for 1–30 min. A multiple linear regression analysis was performed to identify the effect of the mixing conditions on each physicochemical property. The mixing conditions did not significantly affect the lubrication properties of TR-FB. For tablet properties, tensile strength decreased and disintegration time increased when the lubricant concentration and the mixing time were increased for Mg-St. The direct interaction of the Mg-St concentration and the mixing time had a significant negative effect on the disintegration time. In contrast, any mixing conditions of TR-FB did not affect the tablet properties. In addition, the range of mixing conditions which satisfied the lubrication and tablet property criteria was broader for TR-FB than that for Mg-St, suggesting that TR-FB allows tablets with high quality attributes to be produced consistently. Therefore, TR-FB is a potential lubricant alternative to Mg-St.
収録刊行物
-
- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
-
ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 61 (11), 1143-1148, 2013
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679155729792
-
- NII論文ID
- 130003381780
-
- NII書誌ID
- AA00602100
-
- COI
- 1:STN:280:DC%2BC2c7ivFyjuw%3D%3D
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 024957170
-
- PubMed
- 24189302
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可