-
- Matsumoto Yotaro
- Faculty of Pharmaceutical Sciences, Teikyo University
-
- Ito Akihiro
- Chemical Genetics Laboratory, RIKEN Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science
-
- Uesugi Motonari
- Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University Institute for Chemical Research, Kyoto University
-
- Kittaka Atsushi
- Faculty of Pharmaceutical Sciences, Teikyo University
書誌事項
- タイトル別名
-
- Efficient <i>N</i>-Acyldopamine Synthesis
この論文をさがす
抄録
N-Acyldopamines are endogenous analogs of capsaicin that exhibit cannabinoid-like activities and were identified from brain extracts. Among them, N-arachidonoyldopamine (AADA) and N-oleoyldopamine (ODA) were characterized as transient receptor potential vanilloid type V1 channel (TRPV1) ligands. Recently, it was shown that N-acyldopamines may possess diverse physiological roles in addition to their ligand activities. To study the multiple functions and action mechanisms of endogenous N-acyldopamines, a simple and efficient method of N-acyldopamine synthesis was investigated. The eighteen potentially endogenous N-acyldopamines and two deuterated ones, N-palmitoyl dopamine-d5 and N-stearoyl dopamine-d5, were efficiently synthesized without protective groups in CH2Cl2 under optimized conditions using propylphosphoric acid cyclic anhydride (PPACA) as a condensation agent.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 64 (7), 935-940, 2016
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679155841280
-
- NII論文ID
- 130005160071
-
- NII書誌ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL書誌ID
- 027451733
-
- PubMed
- 27373649
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可