Synthesis of Some Novel Thiocyanotopurine Derivatives and Investigation of Their Antimicrobial Activity and DNA Interactions
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- Dilek Çelik Gülay
- Department of Chemistry, Gazi University
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- Dişli Ali
- Department of Chemistry, Gazi University
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- Öner Yağmur
- Department of Biology, Gazi University
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- Açık Leyla
- Department of Biology, Gazi University
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説明
A series of 6-thiocyanatopurine derivatives introduced with different alkyl groups in position 9 was synthesized. The structures of the synthesized compounds were evaluated via spectroscopic methods and elemental methods of analyses. All the synthesized compounds were screened for their antibacterial activities against Gram-positive and Gram-negative bacteria and for their antifungal activities against yeast strains. All the synthesized compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. DNA interactions with pBR322 DNA were determined. Most of the compounds caused conformational changes in DNA.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 60 (5), 578-582, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679155850368
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- NII論文ID
- 130001852453
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC38jgvFamsQ%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 023593354
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- PubMed
- 22689394
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可