Stilbene Glucoside, a Putative Sleep Promoting Constituent from Polygonum multiflorum Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase

DOI Web Site Web Site PubMed 参考文献33件
  • Wei Qian
    Heart Disease Diagnosis and Treatment Center, The Affiliated Hospital to Changchun University of Chinese Medicine
  • Ta Guang
    Department of Emergency and ICU, The Affiliated Hospital to Changchun University of Chinese Medicine
  • He Wenjing
    Department of Emergency and ICU, The Affiliated Hospital to Changchun University of Chinese Medicine
  • Wang Wei
    Department of Emergency and ICU, The Affiliated Hospital to Changchun University of Chinese Medicine
  • Wu Qiucheng
    Department of Emergency and ICU, The Affiliated Hospital to Changchun University of Chinese Medicine

書誌事項

タイトル別名
  • Stilbene Glucoside, a Putative Sleep Promoting Constituent from <i>Polygonum multiflorum</i> Affects Sleep Homeostasis by Affecting the Activities of Lactate Dehydrogenase and Salivary Alpha Amylase

この論文をさがす

説明

<p>Chinese herbal medicine (CHM) has been used for treating insomnia for centuries. The most used CHM for insomnia was Polygonum multiflorum. However, the molecular mechanism for CHM preventing insomnia is unknown. Stilbene glucoside (THSG), an important active component of P. multiflorum, may play an important role for treating insomnia. To test the hypothesis, Kunming mice were treated with different dosages of THSG. To examine the sleep duration, a computer-controlled sleep-wake detection system was implemented. Electroencephalogram (EEG) and electromyogram (EMG) electrodes were implanted to determine sleep-wake state. RT-PCR and Western blot was used to measure the levels of lactate dehydrogenase (LDH) and saliva alpha amylase. Spearman’s rank correlation coefficient was used to identify the strength of correlation between the variables. The results showed that THSG significantly prolonged the sleep time of the mice (p<0.01). THSG changed sleep profile by reducing wake and rapid eye movement (REM) period, and increasing non-REM period. RT-PCR and Western blot analysis showed that THSG could down-regulate the levels of LDH and saliva alpha amylase (p<0.05). The level of lactate and glucose was positively related with the activity of LDH and saliva alpha amylase (p<0.05), respectively. On the other hand, the activities of LDH and amylase were negatively associated with sleep duration (p<0.05). The levels of lactate and glucose affect sleep homeostasis. Thus, THSG may prevent insomnia by regulating sleep duration via LDH and salivary alpha amylase.</p>

収録刊行物

参考文献 (33)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ