New Rotenoids and Coumaronochromonoids from the Aerial Part of Boerhaavia erecta

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  • Do Thi My Lien
    Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City
  • Truong Anh Vu
    Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City
  • Pinnock Travis George
    Department of Physical, Environmental and Computer Sciences, Medgar Evers College, The City University of New York
  • Pratt Lawrence Michael
    Department of Physical, Environmental and Computer Sciences, Medgar Evers College, The City University of New York
  • Yamamoto Shigeki
    Department of Chemistry, School of Science and Technology, Kwansei Gakuin University
  • Watarai Hitoshi
    Institute for Nanoscience Design, Osaka University
  • Guillaume Dominique
    School of Pharmacy
  • Nguyen Kim Phi Phung
    Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City

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  • New Rotenoids and Coumaronochromonoids from the Aerial Part of <i>Boerhaavia erecta</i>

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説明

From the aerial part of Boerhaavia erecta L., three new rotenoids (3, 8, 10) and two new coumaronochromonoids (6, 11) were isolated, together with ten known compounds. The structure of the new compounds was established by one dimensional (1D)- and 2D-NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of compound 11 was determined by UV circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 µg/mL. Rotenoids 3, 4 and 5 showed a strong cytotoxic activity against HeLa cell line and rotenoids 5 and 8 showed good activity against MCF-7 cell line.

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