Medicinal Flowers(40)Structures of Dihydroisocoumarin Glycosides and Inhibitory Effects on Aldose Reducatase from the Flowers of Hydrangea macrophylla var. thunbergii
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- Liu Jiang
- Kyoto Pharmaceutical University
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- Nakamura Seikou
- Kyoto Pharmaceutical University
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- Zhuang Yan
- Kyoto Pharmaceutical University
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- Yoshikawa Masayuki
- Kyoto Pharmaceutical University
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- Hussein Ghazi Mohamed Eisa
- Kyoto Pharmaceutical University
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- Matsuo Kyohei
- Kyoto Pharmaceutical University
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- Matsuda Hisashi
- Kyoto Pharmaceutical University
書誌事項
- タイトル別名
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- Medicinal Flowers. XXXX.<sup>1)</sup> Structures of Dihydroisocoumarin Glycosides and Inhibitory Effects on Aldose Reducatase from the Flowers of <i>Hydrangea macrophylla</i> var. <i>thunbergii</i>
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Six dihydroisocoumarin glycosides, florahydrosides I and II, thunberginol G 8-O-β-d-glucopyranoside, thunberginol C 8-O-β-d-glucopyranoside, 4-hydroxythunberginol G 3′-O-β-d-glucopyranoside, and thunberginol D 3′-O-β-d-glucopyranoside, have been isolated from the flowers of Hydrangea macrophylla Seringe var. thunbergii Makino (Saxifragaceae) together with 20 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, acylated quinic acid analog, neochlorogenic acid, was shown to substantially inhibit aldose reductase [IC50=5.6 µm]. In addition, the inhibitory effects on aldose reductase of several caffeoylquinic acid analogs were examined for structure–activity relationship study. As the results, 4,5-O-trans-p-dicaffeoyl-d-quinic acid was found to exhibit a potent inhibitory effect [IC50=0.29 µm].
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 61 (6), 655-661, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679156009728
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- NII論文ID
- 130003360792
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3snovV2luw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024523991
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- PubMed
- 23727779
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可