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- 立松 正衞
- 愛知県がんセンター研究所腫瘍病理
書誌事項
- タイトル別名
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- Inhibition of gastric carcinogenesis in the Helicobacter pylori infection model employing Mongolian gerbils.
- キョウイク コウエン H pylori カンセン スナネズミ ジッケン イガン ノ ヨクセイ
この論文をさがす
抄録
Helicobacter pylori (Hp) has been classified as a stomach carcinogen on the basis of epidemiological findings. For detailed analysis of the role of Hp in stomach carcinogenesis, it is essential to establish a small animal model. Hirayama et al. first demonstrated that Mongolian gerbils (MGs) can be infected with Hp. We have established experimental models of stomach carcinogenesis in MGs using the chemical carcinogens, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU). In the present study, male MGs were infected with Hp before or after MNU administration. Glandular stomach adenocarcinomas not only of well-differentiated but also poorly differentiated and signet-ring cell types were induced. The incidence of adenocarcinomas was significantly higher in animals treated with before or after MNU administration than in the controls. Hp infection also enhances glandular stomach carcinogenesis in MGs treated with MNNG. To further assess this latter possibility, male MGs were treated with MNU followed by inoculation with Hp, or infected with Hp followed by MNU administration, then Hp was eradicated in half of the infected animals. The incidence of tumor development in infected animals was significantly higher than in Hp eradicated animals. The incidence was significantly suppressed by the eradication procedure. Our studies have shown that Hp enhances glandular stomach carcinogenesis of MGs treated with chemical carcinogens. Moreover, Hp eradication may be useful as a prevention approach.
収録刊行物
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- 生物物理化学
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生物物理化学 44 (4), 247-250, 2000
日本電気泳動学会
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詳細情報 詳細情報について
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- CRID
- 1390282679177580416
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- NII論文ID
- 130003607222
- 10013221255
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- NII書誌ID
- AN00129729
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- ISSN
- 13499785
- 00319082
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- NDL書誌ID
- 5606985
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可