Spontaneous ocular abnormalities in Crl:CD(SD) rats

DOI
  • BAN Yoshiki
    Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd.
  • TOMOHIRO Masayuki
    Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd.
  • INAGAKI Satoru
    Preclinical Regulatory Affairs, Clinical Development Institute, Banyu Pharmaceutical Co., Ltd.
  • KUNO Hiroshi
    Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co., Ltd.

Bibliographic Information

Other Title
  • Crl:CD(SD)ラットにおける自然発生眼病変

Search this article

Description

Ophthalmic examinations were conducted with accumulation of historical control data in Crl:CD(SD) rats from 2004 to 2007 and the spontaneous ocular abnormalities were analyzed. A total of 484 control rats from 22 toxicological studies were examined with slit lamp biomicroscopy and indirect ophthalmoscopy. The age of animals at examination ranged from 8 to 31 weeks and the number of control animals per study was 10 to 20 per sex.<br>There was a high incidence of ocular abnormalities in the cornea and lens with incidences of 47% and 31%, respectively. These abnormalities consisted of opacities. The corneal finding observed mostly was interpalpebral punctate opacity. The lens opacities were observed in the anterior subcapsular, anterior cortical, cortical nuclear junction, nuclear, posterior cortical and posterior capsular. Of the lens opacities, nuclear changes were observed with the highest incidence of 23% and the anterior cortical opacities were observed with the second highest incidence of 8%. The incidence of ocular abnormalities in the conjunctiva, iris, vitreous, retina and choroid were 2% and below. The incidence of corneal and lens opacities were very variable depending on the lot of rats and were not very related to age range examined.

Journal

  • Animal Eye Research

    Animal Eye Research 27 (0), 9-15, 2008

    Japanese Society of Comparative and Veterinary Ophthalmology

Keywords

Details 詳細情報について

Report a problem

Back to top