-
- 服部 浩一
- 東京大学医科学研究所幹細胞治療研究センター幹細胞制御分野
-
- 田代 良彦
- 東京大学医科学研究所幹細胞治療研究センター幹細胞制御分野 順天堂大学医学部下部消化管外科
-
- Beate Heissig
- 東京大学医科学研究所幹細胞治療研究センター幹細胞制御分野
書誌事項
- タイトル別名
-
- Bone marrow-derived cells play a key role in tissue regeneration
- コツズイ ユライ サイボウ ドウイン オ カイシタ ソシキ サイセイ セイギョ キコウ
この論文をさがす
説明
Vascular endothelial growth factor (VEGF) regulates vasculogenesis and angiogenesis by signaling through two tyrosine kinase receptors, VEGF receptor-1(VEGFR1) and VEGFR2. Whereas VEGF/VEGFR2 signaling contributes to the regulation of endothelial cell lineage differentiation and proliferation, VEGF/VEGFR1 signaling in hematopoietic lineage cells can promote the mobilization of hematopoietic stem cells and induce bone marrow regeneration. These data suggest that there is a significant interaction between post-natal angiogenesis and hematopoiesis.<br> We reported that the activation of VEGF/VEGFR and chemokine stromal cell-derived factor-1(CXCL12)/CXCR4 signal pathways induce the mobilization of bone marrow-derived hematopoietic lineage cells. It was shown that these pathways regulate bone marrow cell differentiation and proliferation by activating matrix metalloproteinases (MMP) causing MMP-mediated hematopoietic factor, Kit ligand processing. Moreover, we have also reported that CXCL12 and VEGF are released from bone marrow-derived inflammatory cells like neutrophils or platelets.<br> It was demonstrated that CXCR4 positive and VEGFR1 positive lineage cells, also called hemangiocytes, can produce angiopoetin-2 which can recruit hematopoietic stem cells from the bone marrow and work as molecular HUB by augmenting revascularization in the “neo-vascular niche”. Recently, we showed that activation of the fibrinolytic system resulted in the constitutive activation of MMPs causing Kit ligand release, which promoted bone marrow regeneration after myelosuppression. These data imply that the fibrinolytic system might also play a role in regulating neoangiogenesis during tissue regeneration. Here, we will introduce recent studies from our group and several novel concepts in our current understanding of the regulation of angiogenesis.<br>
収録刊行物
-
- 生物物理化学
-
生物物理化学 53 (4), 109-114, 2009
日本電気泳動学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679178886016
-
- NII論文ID
- 10026143082
-
- NII書誌ID
- AN00129729
-
- ISSN
- 13499785
- 00319082
-
- NDL書誌ID
- 10549984
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
