日本における希なＰＧＭ１６家系について

DOI オープンアクセス
  • 吉田 宏
    帝京大学医学部法医学教室
  • 小野 政孝
    新潟大学医学部法医学教室, 新潟県警科学捜査研究所

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タイトル別名
  • Rare PGM16-1 and PGM16-2 types in a Japanese family.

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説明

Extensive studies on the population of PGM1 polymorphism in human red cells have been studied. Three commonly phenotypes designated as PGM11-1, PGM12-1 and PGM12-2, have been characterized by using the starch gel electrophoresis. However, some rare phenotypes i. e., PGM13-1, PGM1 5-1, PGM16-1, and PGM18-1, have not fully characterized.<br>We conducted the study of PGM16-1 and PGM16-2 types in red cell lysates from members of a Japanese family.<br>The proband of the variant was a patient with liver diseases during a medical treatments. From this family of ten individuals, three showed PGM16-1 type and one had a PGM16-2 type. Our experimental method for the determination of PGM1 isoenzymes consisted of starch gel electrophoresis and isoelectric focusing using polyacrylamide gel with a pH range 5∼7. This paper report an unusual phenomenon of three bands which are characterized for PGM16 phenotype by isoelectric focusing when two bands are generally obtained by starch gel electrophoresis for the same individuals.

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