Safety Assessment of Electronic Cigarettes in Smokers

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  • MIURA Katsuyuki
    Departments of Applied Pharmacology and Therapeutics, Osaka City University Medical School
  • KIKUKAWA Yuko
    Center for Drug and Food Clinical Evaluation, Osaka City University Hospital
  • NAKAO Takafumi
    Center for Drug and Food Clinical Evaluation, Osaka City University Hospital Pharmacology, Osaka City University Medical School
  • TOKAI Hidekiti
    Center for Drug and Food Clinical Evaluation, Osaka City University Hospital
  • IZUMI Yasukatsu
    Pharmacology, Osaka City University Medical School
  • FUJII Hisako
    Center for Drug and Food Clinical Evaluation, Osaka City University Hospital
  • HOJO Taisuke
    Center for Drug and Food Clinical Evaluation, Osaka City University Hospital

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Other Title
  • 喫煙者を対象とした電子タバコの安全性確認試験
  • キツエンシャ オ タイショウ ト シタ デンシ タバコ ノ アンゼンセイ カクニン シケン

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Abstract

In order to assess the safety of electronic cigarettes, 32 smokers who consume more than 20 tobacco cigarettes daily were enrolled in the present study. The cartridge of an electronic cigarette contains 0.25 g of glycerin aqueous solution. Each participant was asked to consume one filter cartridge per day (more than 150 puffs per day) for 4 weeks. Following the treatment, no abnormal changes in blood pressure, hematological data, or blood chemistry and no severe adverse events were observed. Although a trace amount of acrolein was detected in the vapor collected from a single filter cartridge, it was less than the minimum amount in the mainstream smoke from a single tobacco cigarette. During the use of the electronic cigarette, the daily consumption of tobacco cigarettes decreased significantly. This electronic cigarette containing glycerin aqueous solution may be a safe alternative to cigarette smoking.

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