Anti-inflammatory Effect of DHA-bound Phospholipids -Suppression of Platelet Activating Factor (PAF) Activity-

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  • ＤＨＡ結合型リン脂質による抗炎症効果　　―抗血小板活性化因子（ＰＡＦ）作用―
  • DHA ケツゴウガタ リン シシツ ニ ヨル コウエンショウ コウカ コウケッショウバン カッセイカ インシ PAF サヨウ
  • —Suppression of Platelet Activating Factor (PAF) Activity—
  • ―抗血小板活性化因子（PAF）作用―

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Abstract

Unique physiological functions of DHA-bound phospholipids, comparable with those of fish oil (triglyceride), have been reported in several papers. We investigated the effect of DHA-bound phospholipids (squid-PL) on PAF receptor in the present study. We found that squid-PL reduced the incidence of PAF binding to PAF receptor by 63% (200μg/ml). We further found that the PL concentration of 1000g/ml, reduced PAF-induced platelet aggregation by 55%. These physiological effects of squid-PL were able to reduce the fatality rate in mouse following PAF administration. An antagonistic effect of squid-PL against PAF receptor was thus demonstrated.

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