Anti-inflammatory Effect of DHA-bound Phospholipids -Suppression of Platelet Activating Factor (PAF) Activity-
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- KANADA Teruyuki
- Bizen Chemical Co., Ltd
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- KUYAMA Toru
- Bizen Chemical Co., Ltd
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- HADA Takahiko
- Bizen Chemical Co., Ltd
Bibliographic Information
- Other Title
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- DHA結合型リン脂質による抗炎症効果 ―抗血小板活性化因子(PAF)作用―
- DHA ケツゴウガタ リン シシツ ニ ヨル コウエンショウ コウカ コウケッショウバン カッセイカ インシ PAF サヨウ
- —Suppression of Platelet Activating Factor (PAF) Activity—
- ―抗血小板活性化因子(PAF)作用―
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Description
Unique physiological functions of DHA-bound phospholipids, comparable with those of fish oil (triglyceride), have been reported in several papers. We investigated the effect of DHA-bound phospholipids (squid-PL) on PAF receptor in the present study. We found that squid-PL reduced the incidence of PAF binding to PAF receptor by 63% (200μg/ml). We further found that the PL concentration of 1000g/ml, reduced PAF-induced platelet aggregation by 55%. These physiological effects of squid-PL were able to reduce the fatality rate in mouse following PAF administration. An antagonistic effect of squid-PL against PAF receptor was thus demonstrated.
Journal
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- SEIKATSU EISEI (Journal of Urban Living and Health Association)
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SEIKATSU EISEI (Journal of Urban Living and Health Association) 51 (5), 317-320, 2007
Osaka Urban Living and Health Association
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Details 詳細情報について
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- CRID
- 1390282679183412736
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- NII Article ID
- 130004809676
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- NII Book ID
- AN00126141
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- ISSN
- 18836631
- 05824176
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- NDL BIB ID
- 8966065
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed