Changes in oral LD50 values for heavy metals by pretreatment with the same metals.

DOI
  • MORITA Shigeru
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences

Bibliographic Information

Other Title
  • 重金属の前投与がＬＤ５０値におよぼす影響

Search this article

Description

Oral LD50 values (at 24- and 168-hr) for eight metal salts were determined in female ICR mice pretreated orally with small doses (1/10 of the challenge doses) of the same metal ions or with deionized water at 24hr prior to the challenge doses. The LD50 values for Cd2+ or Mn2+ increased with pretreatment by the same ion, but those for Hg2+ decreased. Pretreatment with Cu2+, Fe2+, Fe3+, Pb2+ or Zn2+ had little effect on the lethality of the same ion. Cd2+ pretreatment was the most effective in reducing the acute toxicity of the same ion. Pretreatment with Cu2+ Hg2+ or Zn2+ protected mice against the toxic action of Cd2+.

Journal

Details 詳細情報について

  • CRID
    1390282679183815552
  • NII Article ID
    130003877491
  • DOI
    10.11468/seikatsueisei1957.29.274
  • ISSN
    18836631
    05824176
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top