Analysis of cancer stem cells in an oral squamous cell carcinoma cell line

DOI Web Site 11 References
  • Ohnishi Yuichi
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Minamino Yuki
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Watanabe Masahiro
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Ugaki Yoshihide
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Dateoka Suguru
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Inoue Hiroshi
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Akane Masaki
    Department of Oral and Maxillofacial Surgery, Osaka Kaisei Hospital
  • Nakajima Masahiro
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Kakudo Kenji
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

Bibliographic Information

Other Title
  • 口腔扁平上皮癌細胞株に含まれる癌幹細胞の解析
  • コウコウ ヘンペイ ジョウヒガン サイボウカブ ニ フクマレル ガン カン サイボウ ノ カイセキ

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Abstract

Cancer stem cells of oral squamous cell carcinoma (OSCC) are reported to have relevance to growth, differentiation and proliferation of the tumor. OSCC, like many solid tumors, contains a heterogeneous population of cancer cells. Recent data suggest that a rare subpopulation of cancer cells, termed cancer stem cells (CSC), is capable of initiating, maintaining, and expanding the growth of tumors. Identification and characterization of CSC from OSCC facilitates the monitoring, therapy, and prevention of OSCC. We investigated oral cancer stem-like cells (OC-SLC) through sphere formation by cultivating OSCC cells from established OSCC cell lines within a defined serum-free medium and under anchorage independent conditions. Although HSC3 and HSC4 cells did not promote growth, SAS cells did. Sphere formation was also noted. These findings suggest that SAS possesses the characteristic of CSC.

Journal

  • Shikaigaku

    Shikaigaku 75 (2), 76-80, 2012

    Osaka Odontological Society

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