Epidemiology of Visceral Mycoses in Patients with Leukemia and MDS-Analysis of the Data in Annual of Pathological Autopsy Cases in Japan in 1989, 1993, 1997 and 2001-

DOI Web Site PubMed 36 Citations 50 References
  • Kume Hikaru
    Dept. of Pathology, School of Medicine, Kitasato University
  • Yamazaki Toshikazu
    Kamakura Research Laboratories, Chugai Pharmaceutical Co., LTD.
  • Abe Michiko
    Faculty of Hygienic Technology, Kitasato University School of Allied Health Sciences
  • Tanuma Hiroyuki
    Dept. of Dermatology, School of Medicine, Kitasato University
  • Okudaira Masahiko
    Dept. of Pathology, School of Medicine, Kitasato University
  • Okayasu Isao
    Dept. of Pathology, School of Medicine, Kitasato University

Bibliographic Information

Other Title
  • 白血病（ＭＤＳを含む）剖検例における内臓真菌症の疫学―日本病理剖検輯報（１９９０，１９９４，１９９８，２００２年版）の解析―
  • ハッケツビョウ(MDS オ フクム)ボウケンレイ ニ オケル ナイゾウ シンキンショウ ノ エキガク : ニホン ビョウリ ボウケンシュウホウ(1990,1994,1998,2002ネンバン)ノ カイセキ
  • — Analysis of the Data in Annual of Pathological Autopsy Cases in Japan in 1989, 1993, 1997 and 2001 —
  • ―日本病理剖検輯報 (1990, 1994, 1998, 2002年版) の解析―

Search this article

Abstract

To study the changes of visceral mycoses in autopsy cases, data on visceral mycosis cases with leukemia and myelodysplastic syndrome (MDS) reported in the Annual of the Pathological Autopsy Cases in Japan in 1989, 1993, 1997 and 2001 were analyzed. The frequency rate of visceral mycoses with leukemia and MDS was 27.9% (435/1,557) in 1989, 23.0% (319/1,388) in 1993, 22.3% (246/1,105) in 1997 and 25.1% (260/1,037) in 2001, which was clearly higher than the rate of cases without leukemia and MDS: 3.4%, 2.7%, 3.5% and 3.7%, respectively. Furthermore, in comparing the rate of mycoses in recipients of stem cell transplantation with that of non-recipients, that of recipients was about 10% higher. The predominant causative agents were Candida and Aspergillus, at approximately the same rate (Candida 33.6%, Aspergillus 33.3%) as in 1989. However, Aspergillus increased conspicuously in 1993 (Candida 22.3% Aspergillus 44.5%), and continued to increase (Candida 22.8%, Aspergillus 50.8% in 1997; Candida 16.9%, Aspergillus 54.2% in 2001). In aspergillosis and zygomycosis, the lung and bronchi comprised the most commonly infected organs: 74.7% and 75.6% of the total cases, respectively. Among a total of 1,260 cases with mycotic infections in the four years studied, acute lymphatic leukemia and acute myeloid leukemia were the major diseases (35.5% and 33.5%, respectively) followed by MDS (29.0%). Given these facts, we emphasize that a greater interest in mycoses should be taken by clinicians, and immunocompromised patients should be protected from opportunistic invasive fungal infections, especially aspergillosis.

Journal

Citations (36)*help

See more

References(50)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top