A Case of Granuloma Trichophyticum Associated with Weber Christian Disease

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  • Weber Christian 病に合併した白癬性肉芽腫の1例

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A 42-year-old man had some erythematous, firmly indurated plaques which persisted for 4 months on the lower abdomen, loins and both thighs. These plaques were diagnosed as Weber Christian disease histologically in August, 1973.<br>His identical twin also had Weber Christian disease and was cured by corticosteroid injection.<br>After a second admission on April 27, 1974, the patient's disease was controlled with high doses of systemic steroid therapy. As a result of long term use of systemic steroids, disseminated intravascular coagulopathy (DIC), herpes zoster, compression fracture of the lumbar vertebra, pleuritis, diabetes mellitus, and diabetic cataract appeared during his hospital stay.<br>Since January, 1975, the patient has been suffering from a ringworm infection of Trichophyton rubrum on the buttocks, groin and both lower extremities. In July, 1975, he noticed a few furuncle-like erythematous nodules on the left leg and the dorsal side of the left ring finger.<br>The biopsy specimens were obtained from the skin lesions three times and the deeper portion of each specimen was cultured on Sabouraud's dextrose agar, which allowed only one type of fungus. It was identified Trichophyton rubrum.<br>The trichophytin test, tuberculin (PPD) and DNCB sensitizing test were negative respectively. Griseofulvin therapy was effective.<br>No case of Trichophyton rubrum granuloma associated with Weber Christian disease has yet been reported in the Japanese literature.

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