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- Fukayama Makiko
- Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
Bibliographic Information
- Other Title
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- 高齢者における抗真菌薬の投与とその問題点
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Description
Incidence and risk factors were analyzed in elderly patients with deep-seated mycosis. Twenty cases with candidiasis or aspergillosis were found in 1, 663 autopsy cases. Intravascular catheters and administration of antibiotics were prominent risk factors for candidiasis, as was steroid therapy. Leukocytopenia due to anti-cancer drugs caused aspergillosis. Preventive use of AMPH in patients with hematological malignancies or with steroid therapy was effective against mycosis. Although AMPH is also effective for almost all kinds of deep-seated mycosis, we rarely administered it to elderly patients because of its nephrotoxicity. The safe use of antimycotics requires checking drug sensitivity of causative fungi in a laboratory, and establishing the optimal dosage for patients with impaired renal function.
Journal
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- Nippon Ishinkin Gakkai Zasshi
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Nippon Ishinkin Gakkai Zasshi 40 (3), 129-133, 1999
The Japanese Society for Medical Mycology
