抗真菌剤の併用効果　Ｉ　　とくにＡｍｐｈｏｔｅｒｉｃｉｎＢとＦｌｕｃｙｔｏｓｉｎｅについて

DOI オープンアクセス

書誌事項

タイトル別名
  • Combined effect of antifungal agents. Fundamental study on amphotericin B and flucytosine.
  • Fundamental Study on Amphotericin B and Flucytosine
  • とくに Amphotericin B と Flucytosine について

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説明

We investigated the combined effect of amphotericin B (AMPH) and flucytosine (5-FC) with emphasis on their combined effect mechanism.<br>Investigations were focused on the susceptibility of four strains of Candida albicans isolated from clinical specimens to AMPH and in combination or alone 5-FC on yeast morphology agar. The cumulative mortality rate and histopathological findings in experimental Candida infections of mice treated with AMPH and/or 5-FC were studied, and determinations were made of intracellular concentrations of 5-FC of C. albicans in yeast nitrogen base with or without AMPH. We also determined the 5-FC levels in serum and various organs, and in urinary excretion of rats after administration of 5-FC alone or in combination of AMPH.<br>Synergistic effect of 5-FC and AMPH was found not only in in vitro but also in vivo experiments. No significant difference in pharmacokinetics of 5-FC by single and combined administration was observed and intracellular levels of 5-FC increased in parallel with the concentration of AMPH added.<br>These results indicated that the synergistic effect of 5-FC and AMPH in combination is caused by stimulation of the uptake of 5-FC into C. albicans cells by AMPH.

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キーワード

詳細情報 詳細情報について

  • CRID
    1390282679188660352
  • NII論文ID
    130003671298
  • DOI
    10.3314/jjmm1960.26.126
  • ISSN
    18846971
    05830516
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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