Superficial dermatomycoses.

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  • 表在性皮膚真菌症

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Recently many new antifingal agents have been developed for the treatment of dermatophytoses, mucocutaneous candidiasis and tinea versicolor. Among them, the agents most commonly used for the treatment of superficial dermatomycoses are the imidazole derivatives such as clotrimazole, miconazole, econazole, isoconazole, tioconazole and ketoconazole. Because these compounds have a broad spectrum of activity, they are effective in the treatment of all types of superficial dermatomycoses. Ketoconazole, especially, is the only orally administered agent among the imidazole derivatives. A double-blind comparison of ketoconazole and griseofulvin in the treatment of patients with tinea unguium was evaluated. At completion of therapy (twenty-four weeks), 39 (90.7%) of 43 patients treated with ketoconazole and 34 (85%) of 40 patients treated with griseofulvin were rated as markedly improved. No significant difference in therapeutic responses have been reported for either treatment group. A 13-year-old girl with chronic mucocutaneous candidiasis, who had failed to improve on conventional therapy, showed a notable clinical response to oral ketoconazole.

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