Biological Activities of Glycoproteins Produced by <i>Candida albicans</i>

DOI

Bibliographic Information

Other Title
  • Ｃａｎｄｉｄａ　ａｌｂｉｃａｎｓ産生糖たんぱくの生物活性

Abstract

Three toxin fractions of glycoprotein nature, which were physicochemically, biologically and immunologically different but closely related with each other, were isolated from a virulent strain of Candida albicans MTU 12024. This paper deals with biological activities of these glycoprotein toxins. All of the three toxins possessed various biological activities, i. e. lethality for mice, Limulus amoebocyte lysate gelling activity, pyrogenicity, plasma coagulation promoting activity, complement activation both in vitro and in vivo, histamine releasing activity, and peripheral lymphocyte transformation inhibition activity. It was found out that these biological activities of the toxins was also provoked by the cellular mannan isolated from the same strain of C. albicans, suggesting a possible synergistic action of the sugar moiety of the toxins.<br>In view of these results as well as of the most plausible location of the toxins, viz. the cell wall, the toxins may be classified into a category of fungal endotoxins.

Journal

Details 詳細情報について

  • CRID
    1390282679188894976
  • NII Article ID
    130003671201
  • DOI
    10.3314/jjmm1960.24.76
  • ISSN
    18846971
    05830516
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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