Biological Activities of Glycoproteins Produced by <i>Candida albicans</i>
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- Yamamoto Yoshimasa
- Department of Microbiology, Meiji College of Pharmacy
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- Iwata Kazuo
- Department of Microbiology, Meiji College of Pharmacy
Bibliographic Information
- Other Title
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- Candida albicans産生糖たんぱくの生物活性
Abstract
Three toxin fractions of glycoprotein nature, which were physicochemically, biologically and immunologically different but closely related with each other, were isolated from a virulent strain of Candida albicans MTU 12024. This paper deals with biological activities of these glycoprotein toxins. All of the three toxins possessed various biological activities, i. e. lethality for mice, Limulus amoebocyte lysate gelling activity, pyrogenicity, plasma coagulation promoting activity, complement activation both in vitro and in vivo, histamine releasing activity, and peripheral lymphocyte transformation inhibition activity. It was found out that these biological activities of the toxins was also provoked by the cellular mannan isolated from the same strain of C. albicans, suggesting a possible synergistic action of the sugar moiety of the toxins.<br>In view of these results as well as of the most plausible location of the toxins, viz. the cell wall, the toxins may be classified into a category of fungal endotoxins.
Journal
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- Japanese Journal of Medical Mycology
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Japanese Journal of Medical Mycology 24 (2), 76-82, 1983
The Japanese Society for Medical Mycology
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Details 詳細情報について
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- CRID
- 1390282679188894976
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- NII Article ID
- 130003671201
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- ISSN
- 18846971
- 05830516
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed