Azacitidine Treatment Following Intensive Chemotherapy with Daunorubicin and Cytarabin for Acute Transformation in Myelodysplastic/Myeloproliferative Neoplasms
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- KAWAKAMI Toru
- Department of Hematology, NHO Matsumoto Medical Center
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- SAKAI Kaoko
- Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine
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- NISHINA Sayaka
- Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine
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- MIMURA Yuto
- Department of Hematology, NHO Matsumoto Medical Center
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- MIYAHIRA Takaaki
- Department of Hematology, NHO Matsumoto Medical Center
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- SENOO Yasushi
- Department of Hematology, NHO Matsumoto Medical Center
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- NAKAZAWA Hideyuki
- Department of Hematology, NHO Matsumoto Medical Center
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- KITANO Kiyoshi
- Department of Hematology, NHO Matsumoto Medical Center
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Abstract
We report here a case of a 70-year-old male with myelodysplastic/myeloproliferative neoplasms (MDS/MPN) having hepatosplenomegaly, mild monocytosis, and normal karyotypes without JAK2 mutation. The patient developed an acute transformation and during the intensive therapy with daunorubicin and cytarabin, diffuse alveolar hemorrhage appeared due to disseminated intravascular coagulopathy. After induction, bone marrow blasts reduced to 5.1%, and the patient received two courses of azacitidine therapy. During these courses, blasts in the peripheral blood were not observed. Intensive chemotherapy consisting of daunorubicin and cytarabin followed by azacitidine therapy might be effective for acute transformation in MDS/MPN.
Journal
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- THE SHINSHU MEDICAL JOURNAL
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THE SHINSHU MEDICAL JOURNAL 62 (3), 167-172, 2014
The Shinshu Medical Society
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Details 詳細情報について
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- CRID
- 1390282679189741056
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- NII Article ID
- 130004551934
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- NII Book ID
- AN00120815
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- ISSN
- 18846580
- 00373826
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- HANDLE
- 10091/17589
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- NDL BIB ID
- 025605272
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed