フルニトラゼパム静注による内視鏡検査時の鎮静法の有用性について

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  • Flunitrazepam. A potent intravenous sedative agent for endoscopy.

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Eighty three patients (107 cases) undergoing ERCP, endoscopic sphincterotomy (EST), endoscopic variceal sclerotherapy (sclerotherapy) and colonoscopy were intravenously administered f lunitrazepam as the preendoscopic medication agent. The drug was diluted in lOml saline and injected intravenously in volume of 0.025 mg/kg. Sedative effects were shown in all cases and in the state of closing eyes verbal responce was observed 96 cases (90%). Amnesic effects were identified in 28 of 30 cases (93%). The mean recovery time was 186 minutes. Depression of systolic blood pressure, greater than 40% compared to the premedicative pressure were obvserved in 5 cases (4.6%). Transient excitement and eupholia were noted in 4 cases (3.7%). The pain durindg endoscopic examination was remembered in 7 cases (6.5%). The only one patient complained of arm pain. Flunitrazepam is a very useful intravenous sedative agent for endoscopy in addition to its strong amnesic action.

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