EFFECT OF CAMPYLOBACTER PYLORI INFECTION ON PAS-ALCIAN BLUE POSITIVE MUCIN IN HUMAN GASTRIC MUCOSA
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- TSUJII Masahiko
- Department of Medicine, Osaka University Medical School
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- KAWANO Sunao
- Division of Gastroenterology, Osaka National Hospital
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- OGIHARA Tatsuo
- Division of Gastroenterology, Osaka National Hospital
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- TSUJI Shingo
- Division of Gastroenterology, Osaka National Hospital
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- TANIMURA Hirohisa
- Division of Gastroenterology, Osaka National Hospital
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- HIJIOKA Taizo
- Division of Gastroenterology, Osaka National Hospital
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- SAKURA Hajime
- Division of Gastroenterology, Osaka National Hospital
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- ITO Toshifumi
- Division of Gastroenterology, Osaka National Hospital
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- HAYASHI Nobuhiko
- Division of Gastroenterology, Osaka National Hospital
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- EGUCHI Hiroshi
- Division of Gastroenterology, Osaka National Hospital
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- MATSUNAGA Takashi
- Division of Gastroenterology, Osaka National Hospital
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- SATO Nobuhiro
- Division of Gastroenterology, Osaka National Hospital
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- KAMADA Takenobu
- Division of Gastroenterology, Osaka National Hospital
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- MATSUI Kuniyasu
- Division of Gastroenterology, Osaka National Hospital
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- TANAKA Michio
- Division of Gastroenterology, Osaka National Hospital
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- TAMURA Kazuya
- Division of Gastroenterology, Osaka National Hospital
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- FUKUI Osamu
- Division of Gastroenterology, Osaka National Hospital
Bibliographic Information
- Other Title
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- Campyrobacter pyloriの人胃粘膜内PAS-Alcian Blue陽性ムチン層に対する影響
Abstract
Recently, it has been reported that Campylobacter pylori (CP) infetion is occasionally associated with gastroduodenal diseases. The mechanism by which CP may cause gastroduodenal mucosal damage, however, is still obscure. The mucin of the gastric mucosa has been recognized as the first defensive factor which can prevent the gastroduodenal mucosal damage. In this study, the content of intracellular PAS-alcian blue (PAS-AB) positive substance was analyzed using the computer-assisted image analyzing system. Two biopsy specimens from the antrum and body, respectivelly, were obtained from 36 patients who had endoscopically normal gastric mucosa. One of the specimens was examined microscopically and microbiologically to detect whether there were any colonies of CP in the specimens. The other of specimens was stained with PAS-AB, and the index of the content of PAS-AB positive substance, which depicts the ratio of PAS-AB positive area to the area of mucosal surface epithelial cell, was calculated. In CP positive subjects, the index of PAS-AB positive substance of the antral mucosa was significantly smaller than that of the body mucosa, while in CP negative subjects, there was no significant difference in the index of PAS-AB positive sustance between the antral and body mucosa. The result suggests that in the presence of CP, the mucin content in the antral mucosa decreases significantly and that the mucosal deffensive mechanism might be weakened in antral mucosal damage induced by CP.
Journal
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- GASTROENTEROLOGICAL ENDOSCOPY
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GASTROENTEROLOGICAL ENDOSCOPY 31 (3), 682-688_1, 1989
Japan Gastroenterological Endoscopy Society
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Details 詳細情報について
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- CRID
- 1390282679195516032
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- NII Article ID
- 130004252734
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- ISSN
- 18845738
- 03871207
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed