EXPERIMENTAL STUDY OF ISCHEMIC COLITIS

DOI
  • NOMURA Koji
    The First Department of Internal Medicine, Yamaguchi University School of Medicine

Bibliographic Information

Other Title
  • 虚血性大腸炎に関する臨床的,実験的研究II.虚血性大腸炎の実験的研究
  • -THE MUCOSAL BLOOD FLOW ON THE STATE OF VARIOUS INTRALUMINAL PRESSURE AND HYPERACTIVE PERISTALSIS-
  • ―大腸粘膜血流測定による成因論の考察―

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Description

Factors leading to ischemic colitis are considered the vessel (artero-sclerosis, artero-spasm, ---), the intestine (high-intraluminal pressure, hyperactive peristalsis, ---) and etc.. Characteristic features of this disease are either longitudinal ulcer or erosion at the site of taenia coli. Therefore, using rabbit, an association between the high-intraluminal pres-sure & hyperactive peristalsis and the colonic mucosal blood flow in both sites of taenia and non-taenia coli was investigated experimentally. As the results, with the pressure of 30 mmHg, the blood flow in both sites was reduced, however, marked reduction at the site of taenia coli was observed. On the state of hyperactive peristalsis after intravenous administration of neostigmin and dinoprost, the average of blood flow in total cases was reduced temporarily, despite that the blood flow in each case was variable. Colonic mucosal blood flow was clearly influenced by the change of intraluminal pressure, showing that particularly the blood flow of the site of taenia coli decreased much more by the high pressure. This may be one of the reasons why longitudinal ulcer is seen frequently at the site of taenia coli. In conclusion, it is strongly considered that the intraluminal pressure might be involved into the etiological factor of ischemic colitis.

Journal

Details 詳細情報について

  • CRID
    1390282679196327296
  • NII Article ID
    130004088993
  • DOI
    10.11280/gee1973b.26.641
  • ISSN
    18845738
    03871207
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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