WHITE GLOBE APPEARANCE IS A NOVEL SPECIFIC ENDOSCOPIC MARKER FOR GASTRIC CANCER : A PROSPECTIVE STUDY
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- YOSHIDA Naohiro
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- DOYAMA Hisashi
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- NAKANISHI Hiroyoshi
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- TSUJI Kunihiro
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- TOMINAGA Kei
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- MATSUNAGA Kazuhiro
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- TSUJI Shigetsugu
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- TAKEMURA Kenichi
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- YAMADA Shinya
- Department of Gastroenterology, Ishikawa Prefectural Central Hospital.
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- TSUYAMA Sho
- Diagnostic Pathology, Ishikawa Prefectural Central Hospital.
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- KATAYANAGI Kazuyoshi
- Diagnostic Pathology, Ishikawa Prefectural Central Hospital.
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- KURUMAYA Hiroshi
- Diagnostic Pathology, Ishikawa Prefectural Central Hospital.
Bibliographic Information
- Other Title
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- 胃癌に特異的な新しい内視鏡的マーカーであるWGA(white globe appearance):前向き研究
Abstract
<p>Background and Aim : White globe appearance (WGA) is a small white lesion with a globular shape that can be identified by magnifying endoscopy with narrow-band imaging (M-NBI). WGA was recently reported as a novel endoscopic marker that can differentiate between gastric cancer (GC) and low-grade adenoma. However, the usefulness of WGA for differentiating GC from noncancerous lesions (NC), including those of gastritis, is unknown. </p><p>Methods : To compare the prevalence of WGA in GC and NC, we carried out a prospective study of 994 patients undergoing gastroscopy. All patients were examined for target lesions that were suspected to be GC. When a target lesion was detected, the presence or absence of WGA in the lesion was evaluated using M-NBI, and all target lesions were biopsied or resected for histopathological diagnosis. Primary endpoint was a comparison of WGA prevalence in GC and NC. Secondary endpoints included WGA diagnostic performance for diagnosing GC. </p><p>Results : A total of 188 target lesions from 156 patients were analyzed for WGA, and histopathological diagnoses included 70 cases of GC and 118 cases of NC. WGA prevalence in GC and NC was 21.4% (15/70) and 2.5% (3/118), respectively (P < 0.001). WGA diagnostic accuracy, sensitivity, and specificity for detecting GC were 69.1%, 21.4%, and 97.5%, respectively.</p><p>Conclusions : WGA prevalence in GC is significantly higher than that in NC. Because WGA is highly specific for GC, the presence of WGA is useful to diagnose GC.</p>
Journal
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- GASTROENTEROLOGICAL ENDOSCOPY
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GASTROENTEROLOGICAL ENDOSCOPY 58 (12), 2449-2457, 2016
Japan Gastroenterological Endoscopy Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679198055936
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- NII Article ID
- 130005251268
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- ISSN
- 18845738
- 03871207
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed