LONG-TERM FOLLOW-UP OF A GASTRIC ADENOCARCINOMA OF THE FUNDIC GLAND TYPE : A CASE REPORT

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  • 長期間経過を追えた微小胃底腺型胃癌の1例

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A 57-year-old woman had undergone endoscopic submucosal dissection (ESD) for early-stage gastric adenocarcinoma 7 years previously. Subsequently, she received treatment for Helicobacter pylori, and underwent endoscopic follow-up once a year. Two years after ESD, follow-up esophagogastroduodenoscopy revealed a discolored lesion, measuring 3 mm in diameter, at the greater curvature of the lower body of the stomach. Although we performed endoscopic biopsy of the lesion three years later, it was difficult to confirm the diagnosis. Seven years after ESD, gastric adenocarcinoma of fundic gland type was suspected based on a biopsy specimen from the lesion. Hence, we performed ESD. Histological examination of the resected specimen confirmed gastric adenocarcinoma of fundic gland type. The lesion was limited to the mucosa. On immunohistochemical analysis, the lesion was partially positive for pepsinogen-I, and positive for the mucin MUC6 ; the MIB-1 labeling index was ≤ 3%. Gastric adenocarcinoma of fundic gland type has been reported to be a new variant of gastric adenocarcinoma. Herein, we report a rare case of a minute gastric adenocarcinoma of fundic gland type that was followed up over a long period.

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