In vitro Chromosome Aberration Test and in vivo Micronucleus Test of Ca-type Garcinia Extract

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  • ONO Hiromi
    Food Development Laboratories, Nippon Shinyaku Co., Ltd.
  • TAMURA Hideyuki
    Toxicology Department, Discovery Research Laboratory, Nippon Shinyaku Co., Ltd.
  • YAMASHITA Yasuhiro
    Toxicology Department, Discovery Research Laboratory, Nippon Shinyaku Co., Ltd.
  • TAMURA Kouichi
    Food Development Laboratories, Nippon Shinyaku Co., Ltd.
  • IWAKURA Keiko
    Toxicology Department, Discovery Research Laboratory, Nippon Shinyaku Co., Ltd.

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  • ガルシニアエキスのｉｎ　ｖｉｔｒｏ染色体異常試験およびｉｎ　ｖｉｖｏ小核試験
  • ガルシニアエキス ノ in vitro センショクタイ イジョウ シケン オヨビ in vivo ショウカク シケン

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Abstract

The induction of chromosome aberration of Ca-type Garcinia cambogia extract containing about 65% (-)-hydroxycitric acid was investigated by use of the chromosome aberration test in cultured Chinese hamster lung cells (CHL/IU) and the micronucleus test in mice. In the chromosome aberration test, Ca-type Garcinia cambogia extract did not increase the number of cells with structural aberration and/or numerical aberrations.<br>The micronucleus test was carried out with bone marrow cells of Slc : ddY male mice after single oral administration of up to 2,000 μg/kg.<br>There was no significant increase in the frequency of micronucleated polychromatic erythrocytes. These results indicate that Ca-type Garcinia cambogia extract does not induce chromosome aberration.

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