Biochemical Effects of <i>Amanita muscaria</i> Extract in Mice

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  • ベニテングタケ抽出物のマウスに及ぼす生化学的影響
  • ベニテングタケ チュウシュツブツ ノ マウス ニ オヨボス セイカガクテキ エ

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Abstract

The biochemical effects of mushroom extracts were studied in order to classify poisonous mushrooms in terms of their biochemical effects; this would provide useful information for clinical treatment. The species of mushrooms studied were Amanita muscaria, Amanita pantherina and Amanita rubrovolvata, which are known to cause nervous system disorder in man.<br>After intraperitoneal injection of aqueous extract of A. muscaria into male mice, biochemical changes in the serum and liver were noted within 3 hours, but the values returned to normal within 6 hours after the injection. The activity of serum cholinesterase was decreased moderately at 30 minutes after the injection. The liver glycogen was decreased at 1 hour after the injection. The blood glucose level was increased at 1 hour and decreased at 3 hours after the injection. The blood urea nitrogen was decreased significantly, but serum transaminase activities were unaffected. Among the poisonous mushrooms examined, A. rubrovolvata was the most potent.

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