Placenta Distribution and Accumulation of Cadmium in Pregnant Rats

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  • カドミウムのラット胎盤内分布と蓄積
  • カドミウム ノ ラット タイバンナイ ブンプ ト チクセキ

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Distribution of cadmium (Cd) in the mother-bodies, its transference to the fetus, and its subcellular distribution in the placentae were investigated in pregnant rats of gestational day 18 following a single or repeated subcutaneous injection of CdCl2 at various periods of gestation.<br>1) Most of Cd injected at any period of gestation was present in the liver and kidney, in which Cd contents were 36.5-39.9% and 1.5-3.3% of the administered dose, respectively. In the mother-bodies, higher concentration of Cd was found in the spleen, heart and uterus than in the blood.<br>2) Transference of Cd to the fetus after parenteral injection of CdCl2 was not so remarkable, but a small amount of Cd was found in the amniotic fluid. It is suggested that Cd may be transferred in part to the fetus through the placentae.<br>3) Concentration of Cd in the placenta after a single injection of CdCl2 on gestational day 15 was extremely high, as compared with that after the injection on gestational day 0. The repeated injection of CdCl2 caused higher concentration of Cd in the placenta than the single injection, when the total amounts of both doses were the same.<br>4) In the placenta, Cd was mostly located in the nuclear and supernatant fractions. In the supernatant fraction obtained from the placenta after injection of CdCl2 on gestational day 15, Cd was predominantly associated with the protein fraction with molecular weight of 20, 000-30, 000 on gel-filtration chromatography.

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