ラットの脂質代謝と薬物代謝酵素系に対する自動酸化油投与の影響

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タイトル別名
  • Effects of the Autoxidized Oils on Lipid Metabolism and Drug Metabolizing Enzyme System in Rats
  • ラット ノ シシツ タイシャ ト ヤクブツ タイシャ コウソケイ ニ タイスル

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Corn oil was autoxidized at room temperature by UV irradiation and four samples were obtained in the course of autoxidation.<br>Peroxide values of the four samples were 202 (SO200), 399 (SO400), 805 (SO800), and 1117 (SO1100) respectively.<br>Each sample was administered to male Wistar rats and its effects on lipid metabolism and drug metabolizing enzyme system were investigated.<br>The results obtained were as follows:<br>(1) In the experiments at a single oral dose (4ml/kg) of autoxidized oils, aniline hydroxylase activity was significantly decreased at SO400 administration, but was increased at SO1100. The content of liver triglyceride was decreased at SO1100. The activity of hepatic δ-aminolevulinic acid synthetase was increased both at SO800 and at SO1100 administration.<br>(2) In the repeated oral dose of SO800 or SO1100 (4ml/kg/day) for 10days or 7days respectively, aniline hydroxylase activity and the ratio of liver weight to body weight were increased at SO1100 administration. However, the activity of drug metabolizing enzymes, the contents of glycogen, microsomal protein, triglyceride, and cytochromes were not altered at SO800 administration.<br>(3) In the experiments of a single intraperitoneal injection (4ml/kg) of SO800, aminopyrine demethylase activity, the contents of microsomal protein and cytochrome P-450 were increased in 2hr after the injection, whereas the content of liver triglyceride was decreased approximately 50% in 6 or 12hr after the injection. On the other hand, the contents of liver triglyceride and serum cholesterol were increased in 24hr after the injection.

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 18 (5), 474-480_1, 1977

    公益社団法人 日本食品衛生学会

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