Effects of Furylfuramide on Pregnant Mice and Fetuses

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  • IMAHORI Akira
    Department of Public Health, Juntendo University, School of Medicine

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  • フリルフラマイドの妊娠マウスおよび胎仔に及ぼす影響
  • フリルフラマイド ノ ニンシン マウス オヨビ タイシ ニ オヨボス エイキョ

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The effect of furylfuramide (2-(2-furyl)-3-(5-nitro-2-furyl) acryl amide) on pregnant mice and fetuses was studied in ICR-JCL mice. In the single oral administration groups, 143, 185, 242, or 313mg/kg of furylfuramide, respectively, was given on the 10th day of gestation. In the dietary administration groups, mixed feed containing either 0.1, 0.2, or 0.5% of furylfuramide was given from the 7th day to the 18th day of gestation.<br>After the single administration, three maternal deaths were observed in two high dosage groups. There were no significant differences in the body weight gain and food consumption between the treated groups and the control during pregnancy.<br>On the 18th day of gestation, fetuses were removed by cesarean section. The enlargement of liver was the most remarkable finding in the pregnant mice of dietary furylfuramide administration groups. High incidence of the fetuses with the 14th rib was observed in the dietary furylfuramide administration groups. But the administration of furylfuramide had no conclusive effects on the fetal death, body weight of living fetuses, and the induction of major malformations even at the maternally toxic dosages.

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