モロヘイヤ種子中の主強心配糖体の同定, 分析及び, マウスに対する経口毒性について

DOI 日本農学文献記事索引 Web Site 被引用文献3件 参考文献22件

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タイトル別名
  • Identification and Analyses of Main Cardiac Glycosides in <i>Corchorus olitorius</i> Seeds and Their Acute Oral Toxicity to Mice
  • モロヘイヤ シュシチュウ ノ シュキョウシンハイトウタイ ノ ドウテイ ブンセ

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Two digitoxigenin glycosides (coroloside and glucoevatromonoside) as well as strophanthidin glycosides (erysimoside, olitoriside, corchoroside A and helveticoside) were identified as main cardiac glycosides in the methanol extract of “Moroheiya” (Corchorus olitorius) seeds. HPLC analyses revealed that C. olitorius seeds collected in Japan contained cardiac glycosides at the level of 0.1-1.0% (wet weight). Also, it was suggested that dark greyish green seeds contained more cardiac glycosides than dark greyish yellow-dark greyish yellow-green seeds. Gluco-(1→6)-olitoriside and olitoriusin which had been reported as the main cardiac glycosides by Mahato et al., were not detected by HPLC and 1H-NMR analyses.<br>The acute oral toxicity of isolated cardiac glycosideswas tested in male ddY mice (6 weeks of age). The LD50 values of a mixture of erysimoside-olitoriside (6:4), and a mixture of coroloside-glucoevatromonoside (1:1) were>500mg/kg. Further toxicity testing could not be carried out because the amounts of the cardiac glycosides isolated were insufficient.

収録刊行物

  • 食品衛生学雑誌

    食品衛生学雑誌 39 (4), 256-265_1, 1998

    公益社団法人 日本食品衛生学会

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