Hepatic DNA Damage in Mice Given Organochlorine Chemicals

DOI

Bibliographic Information

Other Title
  • 有機塩素系化合物投与によるマウス肝臓DNAの損傷について

Abstract

The effects of organochlorine chemicals, mainly pesticides, on DNA single-strand breaks (DNA SSB) and the formation of 8-hydroxydeoxyguanosine (8-OHdG) in DNA were examined in mouse liver. Male mice were treated with organochlorine chemicals per os for 5 days, and killed 4hrs after the last administration. The daily dose of each chemical was about one-fifth of the reported LD50. The chemicals examined were endrin, dieldrin, γ-BHC, chlorpyrifos, heptachlor, pentachloronitrobenzene, pp′-DDT, pentachlorophenol, chlordane, 2, 4-D, mirex, pentachlorobenzene, hexachlorobenzene, chlorobenzilate, methoxychlor and trichloroethylene. The administrations of dieldrin, heptachlor, chlordane, mirex, pentachlorobenzene, hexachlorobenzene, chlorobenzilate, and trichloroethylene significantly increased relative liver weight. The 8-OHdG level in hepatic DNA of vehicle-treated mice was 1.2per 105 dG and comparable values were found in all groups treated with the chemicals. Hepatic DNA SSBs in mice treated with trichloroethylene and pentachlorophenol were significantly enhanced, but the effect was slight.

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Details 詳細情報について

  • CRID
    1390282679203682944
  • NII Article ID
    130003693170
  • DOI
    10.3358/shokueishi.34.68
  • ISSN
    18821006
    00156426
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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