Effect of Heparinoid on Free Thyroxine Concentration in Human Serum

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  • SAKURADA TOSHIRO
    Department of Internal Medicine, Tohoku University School of Medicine
  • TAYAMA SUMIO
    Department of Internal Medicine, Tohoku University School of Medicine
  • SAITO SHINTARO
    Department of Internal Medicine, Tohoku University School of Medicine
  • TORIKAI TATSUO
    Department of Internal Medicine, Tohoku University School of Medicine

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Description

Sodium salt of dextran sulfate ester (MDS-Kowa, Kowa Co., Japan) was administered intravenously to 4 euthyroid subjects, 7 patients with hyperthyroidism and 5 patients with hypothyroidism. Serum FFA rose to the level 4-6 times higher than the preinjection level 15min after the intravenous injection. At the same time, elutable fraction (EF) of T4, free T4, and binding capacity and concentration of TBPA increased, while binding capaty of TBG decreased. Addition of dextran sulfate to serum in vitro caused no change in binding capacity of TBG and EF of T4. Addition of palmitic acid to serum in vitro with increasing concentration resulted in a gradual decrease in the distribution of 131I-T4 to TBG and binding capacity of TBG, while EF of T4 gradually increased. Intravenous injection of dextran sulfate ester following the prior injection of protamine sulfate in dog caused a mild rise in serum FFA, but failed to increase the EF of T4. When reverse-flow paper electrophoresis was carried out after addition of 14C-palmitic acid to sera of normal and TBG-deficient subjects, it was confirmed that palmitic acid bound to albumin and TBG fraction. These results suggest that dextran sulfate ester raises serum FFA first, then the increased FFA combines with TBP at least with TBG, thus competing for binding sites with T4, and released T4 in turn increases free T4 level in the serum.

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